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What is Demerol?

Demerol is a potent prescription drug that helps treat the symptoms of moderate to severe pain. You can take it individually or in combination with other medications. It helps manage short-term pain when other pain treatments, including non-opioid pain medicines, do not treat you well enough or you cannot tolerate them.

Demerol is also available with the generic name meperidine. Demerol generic form comes at a comparatively lesser condition, but you might not get the structure and strength your medical healthcare provider prescribed. Demerol is available as both tablets and injections. It would help if you took Demerol tablets by mouth and Demerol injection as an infusion into a vein. Let a medical healthcare provider give you the injection.

Important Information

You should not use Demerol if you have severe asthma or breathing problems. Demerol can slow down or stop your breathing and may be habit-forming. MAO inhibitors include linezolid, phenelzine, Misuse of medications like Demerol overdose, addiction, or death, especially if you take it without a prescription or if your child accidentally took it.

Taking this medication while pregnancy may cause life-threatening withdrawal symptoms in the mother and newborn baby. Fatal or deadly side effects may occur if you use this drug with alcohol or other medicines that can cause drowsiness or slow breathing.

What to know before taking Demerol?

Before taking it, you must know that concomitant use of opioids with Demerol or another central nervous system (CNS) depressant such as alcohol may result in respiratory depression, profound sedation, coma, and death. Using Demerol tablets or oral solutions with any cytochrome P450 3A4 (CYP3A4) inhibitor may cause an increase in plasma concentrations of this drug, which could prolong adverse reactions and may result in potentially fatal respiratory depression.

Excessive use of Demerol for a longer duration during pregnancy can cause neonatal opioid withdrawal syndrome, life-threatening if you do not start treatment on time.

How to take Demerol?

Take Demerol according to your doctor’s prescription because misuse or improper use of Demerol may cause overdose, addiction, or death. You should not break or crush Demerol tablets and ask for medical help when it comes to injections. It would help if you did not take Demerol for chronic pain treatment. Prolonged use of Demerol pills or oral solution may increase the risk of toxicity such as seizure (or convulsions) from the accumulation of meperidine metabolite.

If you suddenly stop using this medication without prior medical consultation, you might face unpleasant withdrawal symptoms such as:

  • Restlessness, anxiety;
  • Trouble sleeping (insomnia);
  • Thoughts of suicide;
  • Runny nose;
  • Watering eyes;
  • Nausea, muscle aches;
  • Diarrhea, sweating; or
  • Sudden changes in mood or behavior

You need to tell your doctor or pharmacist if you feel like you are having withdrawal symptoms. To prevent withdrawal, your medical healthcare provider might lower your doses gradually.

Demerol dosage

Your medical healthcare provider will decide the Demerol dosage, drug form, and dosing schedule keeping the following factors in mind:

  • Your age and severity of the pain for which you are going through treatment with Demerol;
  • Your initial response to the therapy with Demerol;
  • Other pre-existing medical conditions you have (if you have any); or
  • Drugs you were took earlier or taking currently
  • Usual adult dosage for pain:
  • Oral- 50 mg to 150 mg orally within every 3 to 4 hours as needed; The maximum amount per day should not exceed 600 mg.
  • Parental – 50 mg to 150 mg IM or subcutaneously within every 3 to 4 hours as needed; doctors usually recommend IM administration when you need repetition in your doses
  • Patient-Controlled Analgesia (PCA) – The initial dose should be 10 mg with a range of 1 mg to 5 mg per incremental dose; lockout interval may range from 6 to 10 minutes; your initial response to the drug will decide adjustments in the doses
  • Usual pediatric dosage for pain:
  • Oral – The initial dose should be 1.1 mg to 1.8 mg per kg orally every 3 to 4 hours. The single quantity should be 50 mg to 150 mg. And the maximum amount should not exceed 600 mg.
  • Parental – The initial dose should be 1.1 mg to 1.8 mg per kg IM or subcutaneously within every 3 to 4 hours as needed; doctors usually recommend IM administration when you need repetition in your doses. The maximum single amount should not exceed 50 mg to 150 mg.

Overdose

A Demerol (meperidine) overdose can be hazardous or fatal. If you feel like going through an overdose and have severe symptoms, including passing out or trouble breathing, call 911. If it is hard to wake you up, your attendant or caregiver may offer you naloxone if available. One may take medical help or call the poison control helpline at 1-800-222-1222.

Overdose symptoms of Demerol may include severe drowsiness, slow breathing and heart rate, cold and clammy skin, muscle weakness, fainting, blue-colored lips or skin, or coma.

What to avoid while using Demerol?

Dangerous side effects or death may occur if Demerol occurs with alcohol. So, avoid consuming alcohol while taking Demerol. Avoid performing any hazardous activity or even driving until you know how this medication will affect you. Demerol can cause dizziness or drowsiness resulting in accidents or severe injuries. So, avoid performing any task that requires alertness.

Demerol side effects

Some severe side effects of Demerol may require you to call for medical help instantly or get in touch with your medical healthcare provider right away. Here is a possible list of such severe side effects:

  • Slow or shallow heartbeat;
  • Severe drowsiness;
  • Breathing that interrupts or stops during sleep;
  • weak or shallow breathing;
  • Confusion;
  • Lightheadedness;
  • Severe constipation;
  • Mood swings or changes;
  • Uncontrollable muscle movements;
  • Tremors;
  • Seizure (or convulsions);
  • Nausea and vomiting;
  • Dizziness;
  • Loss of appetite;
  • Weakness; or
  • Worsening tiredness

The common side effects of Demerol usually go away in a few days or a couple of weeks. If it persists or worsens with time, consults your medical healthcare provider. Here is a list of possible common side effects:

  • Drowsiness,
  • Dizziness,
  • Vomiting,
  • Nausea, and
  • Sweating

For further information regarding side effects and the risk it contains, consults your medical healthcare provider. You may also report it to the FDA at 1-800-FDA-1088.

What drugs can interact with Demerol?

Drug interactions may change the course of any medication; either it changes the functioning of the medicine or increases the risk of severe side effects. Taking MAO inhibitors with Demerol may cause a severe (possibly fatal) drug interaction. So, stop taking any MAO inhibitor 14 days before you start using Demerol.

The risk of drug interaction resulting in severe side effects is higher if you take other specific products that may cause drowsiness or breathing problems such as:

  • Other opioid (narcotic) pain or cough relievers including hydrocodone and codeine;
  • Alcohol or marijuana (cannabis);
  • Muscle relaxants like carisoprodol and cyclobenzaprine;
  • Sleep medications or anxiety treatments such as zolpidem, lorazepam, alprazolam; or
  • Antihistamines including cetirizine and diphenhydramine
  • Other products that may interact with Demerol include specific pain medications, naltrexone, or mixed opioid agonist-antagonists, including butorphanol, nalbuphine, pentazocine.
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